Paola Marignani
Dalhousie University, Canada
Biography
Dr. Paola Marignani received her PhD from McMaster University, followed by Postdoctoral fellowships at Harvard, the Samuel Lunenfeld Research Institute and the Ontario Cancer Institute. The Marignani Discovery Research Laboratory uses animal models and high through-put screening strategies to identify novel signalling pathways involved in disease. Dr. Marignani and her team have shown that the tumour suppressor kinase LKB1 is an interacting partner and regulator of the estrogen receptor. More recently her team developed a novel spontaneous mouse model of breast cancer. In this model, proteomic and metabolic profiling of tumours confirm hyperactive mTOR and metabolic activity. By combining multiple platforms, The Marignani Discovery Research Laboratory continues to focus on identifying molecular switches that drive tumourigenesis, conduct pre-clinical trials that evaluate novel targeted therapies and develop clinically relevance animals models of human disease.
Abstract
Abstract : Targeting cancer metabolism to overcome treatment resistance in HER2-positive breast cancer.
