Scott J Tebbutt
University of British Columbia, Canada
Title: Integrated metabolite and RNA biomarker signatures of the late phase asthmatic response
Biography
Biography: Scott J Tebbutt
Abstract
Some asthmatic individuals undergoing allergen inhalation challenge develop an isolated early response whereas others develop a dual response (early plus late response). The late response is associated with inflammation and chronic disease pathobiology, and it is important to develop biomarkers that can predict which individuals might be more susceptible to late phase responses. We are using transcriptomics (RNA-Seq) and metabolomics (mass spectrometry) of peripheral blood to identify molecular patterns that can discriminate allergen-induced isolated early from dual asthmatic responses. Peripheral blood was obtained prior to (pre-) and 2 hours post allergen inhalation challenge from 35 study participants. We are developing analytical tools such as sparse generalized canonical correlation discriminant analysis (SGCCDA) to derive classifier signatures that combine metabolite and RNA biomarkers of the late response.